(2)
Gain-of-function research of concern— The term gain-of-function research of concern means, with respect to the study of viruses—
(A)
the use of genetic engineering or nucleic acid synthesis methods reasonably anticipated to increase a pathogen’s transmissibility, or pathogenicity to humans, or to alter a pathogen’s host tropism to include humans;
(B)
the use of serial passage methods in a laboratory culture or in laboratory animals reasonably anticipated to increase a pathogen’s transmissibility, or pathogenicity to humans, or to alter a pathogen’s host tropism to include humans; or
(C)
any research conducted in a laboratory setting less than Biosafety Level Three that involves pathogens or potential pathogens known to be, or that can be reasonably anticipated to be, infectious to humans through the inhalation route of exposure, and known to cause, or that can be reasonably anticipated to cause, serious to fatal disease.
(3)
Transparent international forensic investigation— The term transparent international forensic investigation, with respect to investigating the origin of SARS–CoV–2, means an inquiry that is objective, data-driven, inclusive of broad expertise, subject to independent oversight, and properly managed to exclude individuals with conflicts of interest and under which the following takes place:
(A)
Relevant research funding agencies, funding contractors, laboratories, and hospitals open their records to examination by the investigative team and grant the investigative team unfettered access to any and all facilities, personnel, and other sites of interest, and to any and all forms of epidemiological or virological data of interest, including serological records pertaining to the earliest confirmed or suspected cases of COVID–19, or cases of similar illnesses that may have been misdiagnosed, which appeared in and around Wuhan in the fall and winter of 2019. Investigators document the veracity and source of the data upon which their analysis is based in a manner that allows independent experts to reproduce their analysis and validate any conclusions they may draw.
(B)
The international team is allowed to perform a full forensic investigation of the Wuhan Institute of Virology, the Wuhan Center for Disease Prevention and Control, and the Wuhan Institute of Biological Products, and all other laboratories in Wuhan that the team might identify as warranting examination. The team is allowed to review the biosafety level under which bat coronavirus research was conducted, and to interview any and all personnel currently or previously employed at those laboratories, or related experts who may have information pertinent to the investigation. All laboratory logs and notebooks kept by Shi Zhengli and other researchers at the Wuhan Institute of Virology who have conducted gain-of-function experiments between 2007 and the date of the enactment of this Act, as well as their published and unpublished work in Chinese and English, are presented in a full and unaltered condition for examination by the team. The team is given unlimited access to the full range of virus cultures, isolates, genetic sequences, databases, and patient specimens stored at these facilities as well as all chimeric synthetic viruses grown in vitro by cell culture passaging or engineered by genomic editing between 2007 and the date of the enactment of this Act. Such access must include the opportunity to examine the Wuhan Institute of Virology’s database of approximately 22,000 samples and virus sequences, including 15,000 taken from bats, which was previously available to the public but taken offline in September 2019. The team is further allowed to examine in full all training procedures in effect at the laboratory prior to the pandemic, including those pertaining to record-keeping and safety procedures and strategies to prevent the accidental escape of potential pathogens.
(C)
The investigative team analyzes in detail all research related to the 293 bat coronaviruses reportedly identified by Shi Zhengli and her team at the Wuhan Institute of Virology between 2012 and 2015, particularly RaTG13, RaBtCoV/4991, and all other viruses from the abandoned copper mine in Mojiang Hani Autonomous County in Yunnan province, where Wuhan Institute of Virology researchers are known to have collected bat virus specimens, including specimens of RaTG13, during the decade preceding the date of the enactment of this Act, including all virus isolates and cultures. The Wuhan Institute of Virology discloses the content of all classified and unpublished studies that the Institute reportedly conducted with the People’s Liberation Army if such studies involved gain-of-function research. The team is able to test all laboratory personnel for antibodies and other serological indicators of past infection of COVID–19. The team is given access to all other records kept by the Wuhan Institute of Virology, including security logs, surveillance video footage, audio recordings, and electronic logs of employees entering and leaving the facility. The investigative team is permitted to take samples and conduct testing of the physical facilities where gain-of-function research has been conducted, including, if necessary, sewer samples. Unfettered access is also granted to the copper mine in Mojiang Hani Autonomous County in Yunnan province referred to in the first sentence of this subparagraph.
(D)
The international team is comprised of members chosen by the governments of the United States, Canada, the United Kingdom, France, the Netherlands, Germany, Australia, Japan, and India. The team includes molecular biologists, virologists, epidemiologists, and experts in biosafety and biosecurity. Individuals who have previously ruled out the possibility of either zoonotic transmission or a laboratory leak are disqualified from participation. The Government of the People's Republic of China may appoint Chinese experts to accompany and advise the team as it conducts its work in the People's Republic of China, but the Government of the People's Republic of China has no authority to dictate the selection of team members and cannot obstruct the participation of any individual selected by the individual's government for the team. The central, provincial, and municipal authorities of the People's Republic of China facilitate the work of the investigative team and refrain from imposing any restrictions on the scope, scale, and duration of the investigation.