---
kind: "section"
citation: "21 C.F.R. § 558.625"
title: "21"
number: "558.625"
heading: "Tylosin."
url: "https://uscodex.org/cfr/21/558.625"
---

# §558.625. Tylosin.

- (a) **Specifications.** Type A medicated articles containing tylosin phosphate.
- (b) **Sponsors.** See sponsor numbers in [§ 510.600(c)](/cfr/21/510.600.md?p=c) of this chapter.
  - (1) **No.** 016592: Type A medicated articles containing 40 or 100 grams per pound (g/lb).
  - (2) **No.** 054771: Type A medicated article containing 40 g/lb.
  - (3) **No.** 058198: Type A medicated articles containing 10, 40, or 100 g/lb.
  - (4) **No.** 066104: Type A medicated articles containing 20 or 40 g/lb.
- (c) **Related tolerances.** See [§ 556.746](/cfr/21/556.746.md) of this chapter.
- (d) **Special considerations.**
  - (1) Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. See [§ 558.6](/cfr/21/558.6.md) for additional requirements.
  - (2) The expiration date of VFDs for tylosin medicated feeds must not exceed 6 months from the date of issuance. VFDs for tylosin shall not be refilled.
  - (3) Type C medicated feeds for cattle may be manufactured from tylosin liquid Type B medicated feeds which have a pH between 4.5 and 6.0 and which bear appropriate mixing directions as follows:
    - (i) **For liquid feeds stored in recirculating tank systems—** Recirculate immediately prior to use for not less than 10 minutes, moving not less than 1 percent of the tank contents per minute from the bottom of the tank to the top. Recirculate daily as described even when not used.
    - (ii) **For liquid feeds stored in mechanical, air, or other agitation-type tank systems—** Agitate immediately prior to use for not less than 10 minutes, creating a turbulence at the bottom of the tank that is visible at the top. Agitate daily as described even when not used.
  - (4) Tylosin liquid Type B medicated feeds must bear an expiration date of 31 days after the date of manufacture.
  - (5) Do not use tylosin liquid Type B medicated feeds in any liquid feed containing sodium metabisulfite or in any finished feed (supplement, concentrate, or complete feed) containing in excess of 2 percent bentonite.
- (e) **Conditions of use—**
  - (1) **Swine—**
  - (2) **Cattle—**

## Notes

### Amendments

[40 FR 13959, Mar. 27, 1975]

### Authority

Authority: 21 U.S.C. 354, 360b, 360ccc, 360ccc-1, 371.

### Source

Source: 40 FR 13959, Mar. 27, 1975, unless otherwise noted.

### Amendments

[40 FR 13959, Mar. 27, 1975]