---
kind: "section"
citation: "21 C.F.R. § 558.455"
title: "21"
number: "558.455"
heading: "Oxytetracycline and neomycin."
url: "https://uscodex.org/cfr/21/558.455"
---

# §558.455. Oxytetracycline and neomycin.

- (a) **Specifications.** Type A medicated articles containing oxytetracycline equivalent to 50 grams per pound (g/lb) oxytetracycline hydrochloride and 50 g/lb neomycin sulfate or oxytetracycline equivalent to 100 g/lb oxytetracycline hydrochloride and 100 g/lb neomycin sulfate.
- (b) **Sponsors.** See Nos. 066104 and 069254 in [§ 510.600(c)](/cfr/21/510.600.md?p=c) of this chapter.
- (c) **Related tolerances.** See §§ [556.430](/cfr/21/556.430.md) and [556.500](/cfr/21/556.500.md) of this chapter.
- (d) **Special considerations.**
  - (1) Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. See [§ 558.6](/cfr/21/558.6.md) for additional requirements.
  - (2) The expiration date of VFDs for oxytetracycline and neomycin medicated feeds must not exceed 6 months from the date of issuance. VFDs for oxytetracycline and neomycin shall not be refilled.
  - (3) Cattle feeds shall bear the following warning statement: “Use of more than one product containing neomycin or failure to follow withdrawal times may result in illegal drug residues.”
- (e) **Indications for use—**
  - (1) **Chickens.** It is used in feed as follows:
  - (2) **Turkeys.** It is used in feed as follows:
  - (3) **Swine.** It is used in feed as follows:
  - (4) **Cattle.** It is used in feed as follows:
  - (5) **Sheep.** It is used in feed as follows:
    - (ii) [Reserved]

## Notes

### Amendments

[71 FR 16225, Mar. 31, 2006, as amended at 74 FR 40724, Aug. 13, 2009; 80 FR 13232, Mar. 13, 2015; 81 FR 95012, Dec. 27, 2016; 87 FR 76423, Dec. 14, 2022; 88 FR 27701, May 3, 2023]

### Authority

Authority: 21 U.S.C. 354, 360b, 360ccc, 360ccc-1, 371.

### Source

Source: 40 FR 13959, Mar. 27, 1975, unless otherwise noted.

### Amendments

[71 FR 16225, Mar. 31, 2006, as amended at 74 FR 40724, Aug. 13, 2009; 80 FR 13232, Mar. 13, 2015; 81 FR 95012, Dec. 27, 2016; 87 FR 76423, Dec. 14, 2022; 88 FR 27701, May 3, 2023]