---
kind: "section"
citation: "21 C.F.R. § 558.450"
title: "21"
number: "558.450"
heading: "Oxytetracycline."
url: "https://uscodex.org/cfr/21/558.450"
---

# §558.450. Oxytetracycline.

- (a) **Specifications.** Each pound of Type A medicated article contains:
  - (1) Oxytetracycline (from oxytetracycline quaternary salt) equivalent to 50 or 100 grams oxytetracycline hydrochloride; or oxytetracycline (from oxytetracycline dihydrate base) equivalent to 10, 30, 50, 100, or 200 grams oxytetracycline hydrochloride.
  - (2) Oxytetracycline (from oxytetracycline dihydrate base) equivalent to 50, 100, or 200 grams oxytetracycline hydrochloride; or 100 grams oxytetracycline hydrochloride.
- (b) **Sponsors.** See sponsors in [§ 510.600(c)](/cfr/21/510.600.md?p=c) of this chapter as follows:
  - (1) **No.** 066104: Type A medicated articles as in [paragraph (a)(1)](#a-1) of this section.
  - (2) **No.** 069254: Type A medicated articles as in [paragraph (a)(2)](#a-2) of this section.
- (c) **Related tolerances.** See [§ 556.500](/cfr/21/556.500.md) of this chapter.
- (d) **Special considerations.**
  - (1) Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. See [§ 558.6](/cfr/21/558.6.md) for additional requirements.
  - (2) The expiration date of VFDs for oxytetracycline medicated feeds must not exceed 6 months from the date of issuance. VFDs for oxytetracycline shall not be refilled.
  - (3) In accordance with [§ 558.5](/cfr/21/558.5.md), labeling shall bear the statement: “For use in dry animal feed only. Not for use in liquid feed supplements.”
- (e) **Conditions of use—**
  - (1) **Chickens—**
  - (2) **Turkeys—**
  - (3) **Swine—**
  - (4) **Cattle—**
  - (5) **Minor species—**

## Notes

### Amendments

[81 FR 95009, Dec. 27, 2016, as amended at 82 FR 11512, Feb. 24, 2017; 83 FR 48948, Sept. 28, 2018; 84 FR 12502, Apr. 2, 2019; 86 FR 14825, Mar. 19, 2021; 87 FR 10972, Feb. 28, 2022; 87 FR 76423, Dec. 14, 2022; 88 FR 14907, Mar. 10, 2023; 88 FR 55571, Aug. 16, 2023; 89 FR 85429, Oct. 28, 2024]

### Authority

Authority: 21 U.S.C. 354, 360b, 360ccc, 360ccc-1, 371.

### Source

Source: 40 FR 13959, Mar. 27, 1975, unless otherwise noted.

### Amendments

[81 FR 95009, Dec. 27, 2016, as amended at 82 FR 11512, Feb. 24, 2017; 83 FR 48948, Sept. 28, 2018; 84 FR 12502, Apr. 2, 2019; 86 FR 14825, Mar. 19, 2021; 87 FR 10972, Feb. 28, 2022; 87 FR 76423, Dec. 14, 2022; 88 FR 14907, Mar. 10, 2023; 88 FR 55571, Aug. 16, 2023; 89 FR 85429, Oct. 28, 2024]