---
kind: "section"
citation: "21 C.F.R. § 558.325"
title: "21"
number: "558.325"
heading: "Lincomycin."
url: "https://uscodex.org/cfr/21/558.325"
---

# §558.325. Lincomycin.

- (a) **Specifications.** Type A medicated articles containing 20 or 50 grams of lincomycin (as lincomycin hydrochloride agricultural grade) per pound.
- (b) **Sponsor.** See No. 066104 in [§ 510.600(c)](/cfr/21/510.600.md?p=c) of this chapter.
- (c) **Related tolerances.** See [§ 556.360](/cfr/21/556.360.md) of this chapter.
- (d) **Special considerations.**
  - (1) Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. See [§ 558.6](/cfr/21/558.6.md) for additional requirements.
  - (2) The expiration date of VFDs for lincomycin medicated feeds must not exceed 6 months from the date of issuance. VFDs for lincomycin shall not be refilled.
  - (3) Labeling of Type A medicated articles and Type B and Type C medicated feeds containing lincomycin shall bear the following:
    - (i) “Do not allow rabbits, hamsters, guinea pigs, horses, or ruminants access to feeds containing lincomycin. Ingestion by these species may result in severe gastrointestinal effects.”
    - (ii) [Reserved]
  - (4) Labeling of medicated feeds containing lincomycin intended for use in swine shall bear the following:
    - (i) “Occasionally, swine fed lincomycin may within the first 2 days after the onset of treatment develop diarrhea and/or swelling of the anus. On rare occasions, some pigs may show reddening of the skin and irritable behavior. These conditions have been self-correcting within 5 to 8 days without discontinuing the lincomycin treatment.”
    - (ii) “The effects of lincomycin on swine reproductive performance, pregnancy, and lactation have not been determined.”
- (e) **Conditions of use—**
  - (1) **Chickens—**
  - (2) **Swine—**

## Notes

### Amendments

[81 FR 95005, Dec. 27, 2016, as amended at 82 FR 12170, Mar. 1, 2017; 82 FR 21691, May 10, 2017; 83 FR 13637, Mar. 30, 2018; 83 FR 14588, Apr. 5, 2018; 83 FR 48947, Sept. 28, 2018; 83 FR 64741, Dec. 18, 2018; 84 FR 8976, Mar. 13, 2019; 84 FR 12501, Apr. 2, 2019; 84 FR 39185, Aug. 9, 2019; 86 FR 14824, Mar. 19, 2021; 88 FR 55570, Aug. 16, 2023; 91 FR 20344, Apr. 16, 2026]

### Authority

Authority: 21 U.S.C. 354, 360b, 360ccc, 360ccc-1, 371.

### Source

Source: 40 FR 13959, Mar. 27, 1975, unless otherwise noted.

### Amendments

[81 FR 95005, Dec. 27, 2016, as amended at 82 FR 12170, Mar. 1, 2017; 82 FR 21691, May 10, 2017; 83 FR 13637, Mar. 30, 2018; 83 FR 14588, Apr. 5, 2018; 83 FR 48947, Sept. 28, 2018; 83 FR 64741, Dec. 18, 2018; 84 FR 8976, Mar. 13, 2019; 84 FR 12501, Apr. 2, 2019; 84 FR 39185, Aug. 9, 2019; 86 FR 14824, Mar. 19, 2021; 88 FR 55570, Aug. 16, 2023; 91 FR 20344, Apr. 16, 2026]