---
kind: "section"
citation: "21 C.F.R. § 558.128"
title: "21"
number: "558.128"
heading: "Chlortetracycline."
url: "https://uscodex.org/cfr/21/558.128"
---

# §558.128. Chlortetracycline.

- (a) **Specifications.** Type A medicated articles containing either chlortetracycline calcium complex equivalent to chlortetracycline hydrochloride, or for products intended for use in milk replacer, chlortetracycline hydrochloride.
- (b) **Sponsors.** See sponsors in [§ 510.600(c)](/cfr/21/510.600.md?p=c) of this chapter as follows:
  - (1) **No. 054771—** 50, 70, 80, 90, or 100 grams per pound (g/lb) Type A medicated article.
  - (2) **No. 066104—** 10, 20, 30, 50, 70, or 100 g/lb of Type A medicated article.
  - (3) **No. 069254—** 50, 90, or 100 g/lb of Type A medicated article.
- (c) **Related tolerances.** See [§ 556.150](/cfr/21/556.150.md) of this chapter.
- (d) **Special considerations.**
  - (1) Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. See [§ 558.6](/cfr/21/558.6.md) for additional requirements.
  - (2) The expiration date of VFDs for chlortetracycline medicated feeds must not exceed 6 months from the date of issuance. VFDs for chlortetracycline shall not be refilled.
  - (3) **In milk replacers or starter feed; include on labeling the warning—** “A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.”
  - (4) Manufacture for use in free-choice feeds as in paragraph (e)(4)(vi) of this section must conform to [§ 510.455](/cfr/21/510.455.md) of this chapter.
  - (5) When manufactured for use as in paragraph (e)(5)(iii) of this section, include on labeling the warning: “Psittacosis, avian chlamydiosis, or ornithosis is a reportable communicable disease, transmissible between wild and domestic birds, other animals, and man. Contact appropriate public health and regulatory officials.”
- (e) **Conditions of use—**
  - (1) **Chickens.** It is used as follows:
  - (2) **Turkeys.** It is used as follows:
  - (3) **Swine.** It is used as follows:
  - (4) **Cattle.** It is used as follows:
  - (5) **Minor species.** It is used as follows:
  - (6) **It is used as a free-choice, loose mineral Type C feed as follows—**
    - (i) **Specifications.**
    - (ii) **Amount.** 6,000 grams per ton.
    - (iii) **Indications for use.** Beef and nonlactating dairy cattle: As an aid in the control of active infection of anaplasmosis caused by Anaplasma marginale susceptible to chlortetracycline.
    - (iv) **Limitations.** Feed continuously on a free-choice basis at a rate of 0.5 to 2.0 mg chlortetracycline per pound of body weight per day.
    - (v) **Sponsors.** See Nos. 054771 and 069254 in [§ 510.600(c)](/cfr/21/510.600.md?p=c) of this chapter.

## Notes

### Amendments

[81 FR 94995, Dec. 27, 2016, as amended at 82 FR 21691, May 10, 2017; 82 FR 43485, Sept. 18, 2017; 83 FR 13636, Mar. 30, 2018; 83 FR 14588, Apr. 5, 2018; 83 FR 48947, Sept. 28, 2018; 83 FR 64741, Dec. 18, 2018; 84 FR 8975, Mar. 13, 2019; 84 FR 39185, Aug. 9, 2019; 86 FR 13189, Mar. 8, 2021; 86 FR 14822, Mar. 19, 2021; 86 FR 17064, Apr. 1, 2021; 86 FR 57999, Oct. 20, 2021; 86 FR 61686, Nov. 8, 2021; 87 FR 58963, Sept. 29, 2022; 87 FR 76422, Dec. 14, 2022; 88 FR 14901, Mar. 10, 2023; 88 FR 55567, Aug. 16, 2023; 89 FR 14411, Feb. 27, 2024; 89 FR 95103, Dec. 2, 2024; 90 FR 6801, Jan. 21, 2025]

### Authority

Authority: 21 U.S.C. 354, 360b, 360ccc, 360ccc-1, 371.

### Source

Source: 40 FR 13959, Mar. 27, 1975, unless otherwise noted.

### Amendments

[81 FR 94995, Dec. 27, 2016, as amended at 82 FR 21691, May 10, 2017; 82 FR 43485, Sept. 18, 2017; 83 FR 13636, Mar. 30, 2018; 83 FR 14588, Apr. 5, 2018; 83 FR 48947, Sept. 28, 2018; 83 FR 64741, Dec. 18, 2018; 84 FR 8975, Mar. 13, 2019; 84 FR 39185, Aug. 9, 2019; 86 FR 13189, Mar. 8, 2021; 86 FR 14822, Mar. 19, 2021; 86 FR 17064, Apr. 1, 2021; 86 FR 57999, Oct. 20, 2021; 86 FR 61686, Nov. 8, 2021; 87 FR 58963, Sept. 29, 2022; 87 FR 76422, Dec. 14, 2022; 88 FR 14901, Mar. 10, 2023; 88 FR 55567, Aug. 16, 2023; 89 FR 14411, Feb. 27, 2024; 89 FR 95103, Dec. 2, 2024; 90 FR 6801, Jan. 21, 2025]