---
kind: "section"
citation: "21 C.F.R. § 556.500"
title: "21"
number: "556.500"
heading: "Oxytetracycline."
url: "https://uscodex.org/cfr/21/556.500"
---

# §556.500. Oxytetracycline.

- (a) **Acceptable daily intake (ADI).** The ADI for total tetracycline residues (chlortetracycline, oxytetracycline, and tetracycline) is 25 µg/kg of body weight per day.
- (b) **Tolerances.** The tolerances for the sum of tetracycline residues are:
  - (1) **Cattle.**
    - (i) **Muscle—** 2 ppm.
    - (ii) **Liver—** 6 ppm.
    - (iii) **Fat and kidney—** 12 ppm.
    - (iv) **Milk—** 0.3 ppm.
  - (2) **Chickens and turkeys.**
    - (i) **Muscle—** 2 ppm.
    - (ii) **Liver—** 6 ppm.
    - (iii) **Fat and kidney—** 12 ppm.
  - (3) **Finfish.** Muscle (with adhering skin when edible): 2 ppm.
  - (4) **Lobster.** Muscle: 2 ppm.
  - (5) **Swine and sheep.**
    - (i) **Muscle—** 2 ppm.
    - (ii) **Liver—** 6 ppm.
    - (iii) **Fat and kidney—** 12 ppm.
  - (6) **Honey.** 750 ppb.
- (c) **Related conditions of use.** See §§ [520.1660c](/cfr/21/520.1660c.md), [520.1660d](/cfr/21/520.1660d.md), [520.1664](/cfr/21/520.1664.md), [522.1660a](/cfr/21/522.1660a.md), [522.1660b](/cfr/21/522.1660b.md), [522.1662](/cfr/21/522.1662.md), [522.1664](/cfr/21/522.1664.md), [529.1660](/cfr/21/529.1660.md), [558.450](/cfr/21/558.450.md), and [558.455](/cfr/21/558.455.md) of this chapter.

## Notes

### Amendments

[84 FR 32993, July 11, 2019, as amended at 85 FR 18121, Apr. 1, 2020; 88 FR 16549, Mar. 20, 2023, 88 FR 55567, Aug. 16, 2023]

### Authority

Authority: 21 U.S.C. 342, 360b, 371.

### Source

Source: 84 FR 32993, July 11, 2019, unless otherwise noted.

### Amendments

[84 FR 32993, July 11, 2019, as amended at 85 FR 18121, Apr. 1, 2020; 88 FR 16549, Mar. 20, 2023, 88 FR 55567, Aug. 16, 2023]