---
kind: "section"
citation: "21 C.F.R. § 524.1140"
title: "21"
number: "524.1140"
heading: "Imidacloprid and ivermectin."
url: "https://uscodex.org/cfr/21/524.1140"
---

# §524.1140. Imidacloprid and ivermectin.

- (a) **Specifications.** The product is available in unit applicator tubes containing 0.4, 1.0, 2.5, or 4.0 milliliters (mL). Each mL of solution contains 100 milligrams (mg) imidacloprid and 800 micrograms (µg) ivermectin.
- (b) **Sponsor.** See No. 058198 in [§ 510.600(c)](/cfr/21/510.600.md?p=c) of this chapter.
- (c) **Conditions of Use in Dogs—**
  - (1) **Amount.** The recommended minimum dosage is 4.5 mg/pound (lb) (10 mg/kilogram (kg)) of imidacloprid and 36.4 µg/lb (80 µg/kg) of ivermectin, topically once a month.
  - (2) **Indications for Use.** For the prevention of heartworm disease caused by Dirofilaria immitis; kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis).
  - (3) **Limitations.** Federal law restricts this drug to use by or on the order of a licensed veterinarian.

## Notes

### Amendments

[67 FR 78685, Dec. 26, 2002, as amended at 86 FR 14821, Mar. 19, 2021]

### Authority

Authority: 21 U.S.C. 360b.

### Source

Source: 40 FR 13873, Mar. 27, 1975, unless otherwise noted.

### Amendments

[67 FR 78685, Dec. 26, 2002, as amended at 86 FR 14821, Mar. 19, 2021]