---
kind: "section"
citation: "21 C.F.R. § 522.500"
title: "21"
number: "522.500"
heading: "Cosyntropin injection."
url: "https://uscodex.org/cfr/21/522.500"
---

# §522.500. Cosyntropin injection.

- (a) **Sponsor.** See No. 043264 in [§ 510.600(c)](/cfr/21/510.600.md?p=c) of this chapter.
- (b) **Specifications.** Each milliliter (mL) contains 0.25 milligrams (mg) cosyntropin, 1 mg glacial acetic acid, 0.82 mg sodium acetate trihydrate, 8.1 mg sodium chloride, and water for injection (to 100%).
- (c) **Conditions of use—**
  - (1) **Amount.** Administer 0.25 mg (1 mL) per dog weighing 10-110 pounds (4.5-50 kilograms) by intravenous or intramuscular injection.
  - (2) **Indications for use.** For the evaluation of adrenal function in dogs.
  - (3) **Limitations.** Federal law restricts this drug to use by or on the order of a licensed veterinarian. It is a violation of Federal law to use this product other than as directed in the labeling.

## Notes

### Amendments

[91 FR 20342, Apr. 16, 2026]

### Authority

Authority: 21 U.S.C. 360b.

### Source

Source: 40 FR 13858, Mar. 27, 1975, unless otherwise noted.

### Amendments

[91 FR 20342, Apr. 16, 2026]