---
kind: "section"
citation: "21 C.F.R. § 520.1840"
title: "21"
number: "520.1840"
heading: "Poloxalene."
url: "https://uscodex.org/cfr/21/520.1840"
---

# §520.1840. Poloxalene.

- (a) **Specifications.** Polyoxypropylene-polyoxyethylene glycol nonionic block polymer.
- (b) **Sponsors.** See sponsors in [§ 510.600(c)](/cfr/21/510.600.md?p=c) of this chapter for use as in [paragraph (d)](#d) of this section.
  - (1) **No.** 054771 for use as in paragraphs [(d)(1)](#d-1) and [(d)(3)](#d-3) of this section.
  - (2) **No.** 067949 for use as in [paragraph (d)(2)](#d-2) of this section.
  - (3) **No.** 066104 for use as in [paragraph (d)(3)](#d-3) of this section.
- (c) **Related tolerances.** See [§ 556.517](/cfr/21/556.517.md) of this chapter.
- (d) **Conditions of use.**
  - (1) **For treatment of legume (alfalfa, clover) bloat in cattle.** Administer as a drench at the rate of 25 grams for animals up to 500 pounds and 50 grams for animals over 500 pounds of body weight.
  - (2) **For control of legume (alfalfa, clover) bloat in cattle.** Administer, in molasses block containing 6.6 percent poloxalene, at the rate of 0.8 oz. of block (1.5 grams poloxalene) per 100 lbs. of body weight per day.
  - (3) **For prevention of legume (alfalfa, clover) and wheat pasture bloat in cattle.** A 53-percent poloxalene top dressing on individual rations of ground feed. Dosage is 1 gram of poloxalene per 100 pounds of body weight daily. If bloating conditions are severe, the dose is doubled. Treatment should be started 2 to 3 days before exposure to bloat-producing conditions. Repeat use of the drug if animals are exposed to bloat-producing conditions for more than 12 hours after the last treatment. Do not exceed the double dose in any 24-hour period.

## Notes

### Amendments

[40 FR 13838, Mar. 27, 1975, as amended at 40 FR 39857, Aug. 29, 1975; 42 FR 41854, Aug. 19, 1977; 50 FR 5385, Feb. 8, 1985; 54 FR 33501, Aug. 15, 1989; 56 FR 50653, Oct. 8, 1991; 58 FR 26523, May 4, 1993; 60 FR 55659, Nov. 2, 1995; 66 FR 47963, Sept. 17, 2001; 69 FR 62811, Oct. 28, 2004; 70 FR 32489, June 3, 2005; 78 FR 28826, May 20, 2014; 83 FR 48946, Sept. 28, 2018; 84 FR 32992, July 11, 2019]

### Authority

Authority: 21 U.S.C. 360b.

### Source

Source: 40 FR 13838, Mar. 27, 1975, unless otherwise noted.

### Amendments

[40 FR 13838, Mar. 27, 1975, as amended at 40 FR 39857, Aug. 29, 1975; 42 FR 41854, Aug. 19, 1977; 50 FR 5385, Feb. 8, 1985; 54 FR 33501, Aug. 15, 1989; 56 FR 50653, Oct. 8, 1991; 58 FR 26523, May 4, 1993; 60 FR 55659, Nov. 2, 1995; 66 FR 47963, Sept. 17, 2001; 69 FR 62811, Oct. 28, 2004; 70 FR 32489, June 3, 2005; 78 FR 28826, May 20, 2014; 83 FR 48946, Sept. 28, 2018; 84 FR 32992, July 11, 2019]