---
kind: "section"
citation: "21 C.F.R. § 500.1410"
title: "21"
number: "500.1410"
heading: "N-methyl-2-pyrrolidone."
url: "https://uscodex.org/cfr/21/500.1410"
---

# §500.1410. N-methyl-2-pyrrolidone.

- (a) **Standard for residues.** No residues of n-methyl-2-pyrrolidone may be found in the uncooked edible tissues of cattle and swine as determined by methods in [paragraph (b)](#b) of this section.
- (b) **Incorporation by reference.** The standards required in this section are incorporated by reference into this section with the approval of the Director of the Federal Register under 5 U.S.C. [552(a)](/usc/5/552.md?p=a) and [1](/usc/5/1.md) CFR [part 51](/cfr/21/part51.md). All approved material is available for inspection at the Food and Drug Administration's Dockets Management Staff (HFA-305), 5630 Fishers Lane, Rm. 1061, Rockville, MD 20852, 240-402-7500, between 9 a.m. and 4 p.m., Monday through Friday. It may be obtained from the sources indicated elsewhere in [paragraph (b)](#b) of this section and at: https://www.fda.gov/about-fda/center-veterinary-medicine/cvm-foia-electronic-reading-room. It is also available for inspection at the National Archives and Records Administration (NARA). For information on the availability of this material at NARA, email fr.inspection@nara.gov, or go to: www.archives.gov/federal-register/cfr/ibr-locations.html.
  - (1) Food and Drug Administration, Center for Veterinary Medicine, 7500 Standish Pl., Rockville, MD 20855, 240-402-7002.
    - (i) “Method of Analysis: N-methyl-2-pyrrolidone,” September 26, 2011; the method of analysis for uncooked edible tissues of cattle.
    - (ii) [Reserved]
  - (2) **Merck Animal Health, 29160 Intervet Lane, Millsboro, DE 19966, 1-800-211-3573.**
    - (i) “Determinative and Confirmatory Procedures for the Analysis of N-Methyl-2-pyrrolidone (NMP) in Swine Liver Tissue using LC-MS/MS,” July 20, 2017; the method of analysis for uncooked edible tissues of swine.
    - (ii) [Reserved]
- (c) **Related conditions of use.** See §§ [522.814](/cfr/21/522.814.md), [522.955](/cfr/21/522.955.md), and [522.1660a](/cfr/21/522.1660a.md) of this chapter.

## Notes

### Amendments

[87 FR 10966, Feb. 28, 2022, as amended at 88 FR 55562, Aug. 16, 2023]

### Source

Source: 76 FR 72618, Nov. 25, 2011, unless otherwise noted.

### Authority

Authority: 21 U.S.C. 321, 331, 342, 343, 348, 351, 352, 353, 360b, 371, 379e.

### Source

Source: 40 FR 13802, Mar. 27, 1975, unless otherwise noted.

### Amendments

[87 FR 10966, Feb. 28, 2022, as amended at 88 FR 55562, Aug. 16, 2023]