---
kind: "section"
citation: "21 C.F.R. § 352.20"
title: "21"
number: "352.20"
heading: "Permitted combinations of active ingredients."
url: "https://uscodex.org/cfr/21/352.20"
---

# §352.20. Permitted combinations of active ingredients.


The SPF of any combination product is measured by the testing procedures established in subpart D of this part.

- (a) **Combinations of sunscreen active ingredients.**
  - (1) Two or more sunscreen active ingredients identified in § [352.10(a)](/cfr/21/352.10.md?p=a), [(c)](/cfr/21/352.10.md?p=c), [(e)](/cfr/21/352.10.md?p=e), [(f)](/cfr/21/352.10.md?p=f), and [(h) through (r)](/cfr/21/352.10.md?p=h..r) may be combined with each other in a single product when used in the concentrations established for each ingredient in [§ 352.10](/cfr/21/352.10.md). The concentration of each active ingredient must be sufficient to contribute a minimum SPF of not less than 2 to the finished product. The finished product must have a minimum SPF of not less than the number of sunscreen active ingredients used in the combination multiplied by 2.
  - (2) Two or more sunscreen active ingredients identified in § [352.10(b)](/cfr/21/352.10.md?p=b), [(c)](/cfr/21/352.10.md?p=c), [(e)](/cfr/21/352.10.md?p=e), [(f)](/cfr/21/352.10.md?p=f), [(i) through (l)](/cfr/21/352.10.md?p=i..l), [(o)](/cfr/21/352.10.md?p=o), and [(q)](/cfr/21/352.10.md?p=q) may be combined with each other in a single product when used in the concentrations established for each ingredient in [§ 352.10](/cfr/21/352.10.md). The concentration of each active ingredient must be sufficient to contribute a minimum SPF of not less than 2 to the finished product. The finished product must have a minimum SPF of not less than the number of sunscreen active ingredients used in the combination multiplied by 2.
- (b) **Combinations of sunscreen and skin protectant active ingredients.** Any single sunscreen active ingredient or any permitted combination of sunscreen active ingredients when used in the concentrations established for each ingredient in [§ 352.10](/cfr/21/352.10.md) may be combined with one or more skin protectant active ingredients identified in § [347.10(a)](/cfr/21/347.10.md?p=a), [(d)](/cfr/21/347.10.md?p=d), [(e)](/cfr/21/347.10.md?p=e), [(g)](/cfr/21/347.10.md?p=g), [(h)](/cfr/21/347.10.md?p=h), [(i)](/cfr/21/347.10.md?p=i), [(k)](/cfr/21/347.10.md?p=k), [(l)](/cfr/21/347.10.md?p=l), [(m)](/cfr/21/347.10.md?p=m), and [(r)](/cfr/21/347.10.md?p=r) of this chapter. The concentration of each sunscreen active ingredient must be sufficient to contribute a minimum SPF of not less that 2 to the finished product. The finished product must have a minimum SPF of not less than the number of sunscreen active ingredients used in the combination multiplied by 2, and the product must be labeled according to [§ 352.60](/cfr/21/352.60.md).
- (c) [Reserved]

## Notes

### Amendments

[64 FR 27687, May 21, 1999, as amended at 68 FR 33380, June 4, 2003]

### Authority

Authority: 21 U.S.C. 321, 351, 352, 353, 355, 360, 371.

### Source

Source: 64 FR 27687, May 21, 1999, unless otherwise noted.

### Amendments

[64 FR 27687, May 21, 1999, as amended at 68 FR 33380, June 4, 2003]