---
kind: "section"
citation: "21 C.F.R. § 184.1386"
title: "21"
number: "184.1386"
heading: "Isopropyl citrate."
url: "https://uscodex.org/cfr/21/184.1386"
---

# §184.1386. Isopropyl citrate.

- (a) **Isopropyl citrate is a mixture of the mono-, di-, and triisopropyl esters of citric acid.** It is prepared by esterifying citric acid with isopropanol.
- (b) The ingredient must be of a purity suitable for its intended use.
- (c) In accordance with [§ 184.1(b)(1)](/cfr/21/184.1.md?p=b-1), the ingredient is used in food with no limitation other than current good manufacturing practice. The affirmation of this ingredient as generally recognized as safe (GRAS) as a direct human food ingredient is based upon the following current good manufacturing practice conditions of use:
  - (1) The ingredient is used as an antioxidant as defined in [§ 170.3(o)(3)](/cfr/21/170.3.md?p=o-3) of this chapter; a sequestrant as defined in [§ 170.3(o)(26)](/cfr/21/170.3.md?p=o-26) of this chapter; and a solvent and vehicle as defined in [§ 170.3(o)(27)](/cfr/21/170.3.md?p=o-27) of this chapter.
  - (2) The ingredient is used in margarine in accordance with [§ 166.110](/cfr/21/166.110.md) of this chapter; in nonalcoholic beverages as defined in [§ 170.3(n)(3)](/cfr/21/170.3.md?p=n-3) of this chapter; and in fats and oils as defined in [§ 170.3(n)(12)](/cfr/21/170.3.md?p=n-12) of this chapter at levels not to exceed current good manufacturing practice.
- (d) Prior sanctions for this ingredient different from the uses established in this section, or different from those set forth in [part 181](/cfr/21/part181.md) of this chapter, do not exist or have been waived.

## Notes

### Amendments

[59 FR 63896, Dec. 12, 1994, as amended at 73 FR 8607, Feb. 14, 2008]

### Authority

Authority: 21 U.S.C. 321, 342, 348, 371.

### Source

Source: 42 FR 14653, Mar 15, 1977, unless otherwise noted.

### Amendments

[59 FR 63896, Dec. 12, 1994, as amended at 73 FR 8607, Feb. 14, 2008]