---
kind: "section"
citation: "21 C.F.R. § 172.379"
title: "21"
number: "172.379"
heading: "Vitamin D 2 ."
url: "https://uscodex.org/cfr/21/172.379"
---

# §172.379. Vitamin D 2 .


Vitamin D2 may be used safely in foods as a nutrient supplement defined under [§ 170.3(o)(20)](/cfr/21/170.3.md?p=o-20) of this chapter in accordance with the following prescribed conditions:

- (a) Vitamin D2, also known as ergocalciferol, is the chemical 9,10-seco(5Z,7E,22E)-5,7,10(19),22-ergostatetraen-3-ol. Vitamin D2 is produced by ultraviolet irradiation of ergosterol isolated from yeast and is purified by crystallization.
- (b) Vitamin D2 meets the specifications of the 2015 Food Chemical Codex, 9th edition (through Third Supplement), effective December 1, 2015, pp. 1260-1261, which is incorporated by reference. The Director of the Office of the Federal Register approves this incorporation by reference in accordance with 5 U.S.C. [552(a)](/usc/5/552.md?p=a) and [1](/usc/5/1.md) CFR [part 51](/cfr/21/part51.md). You may obtain copies from the United States Pharmacopeial Convention, 12601 Twinbrook Pkwy., Rockville, MD 20852 (Internet address http://www.usp.org). Copies may be examined at the Dockets Management Staff (HFA-305), Food and Drug Administration, 5630 Fishers Lane, Rm. 1061, Rockville, MD 20852, 240-402-7500, between 9 a.m. and 4 p.m., Monday through Friday, or at the National Archives and Records Administration (NARA). For information on the availability of this material at NARA, call 202-741-6030 or go to: http://www.archives.gov/federal-register/cfr/ibr-locations.html.
- (c) The additive may be used as follows:

## Notes

### Amendments

[74 FR 11022, Mar. 16, 2009, as amended at 78 FR 71463, Nov. 29, 2013; 81 FR 46581, July 18, 2016; 88 FR 17719, Mar. 24, 2023]

### Authority

Authority: 21 U.S.C. 321, 341, 342, 348, 371, 379e.

### Source

Source: 42 FR 14491, Mar. 15, 1977, unless otherwise noted.

### Amendments

[74 FR 11022, Mar. 16, 2009, as amended at 78 FR 71463, Nov. 29, 2013; 81 FR 46581, July 18, 2016; 88 FR 17719, Mar. 24, 2023]