---
kind: "section"
citation: "21 C.F.R. § 170.280"
title: "21"
number: "170.280"
heading: "Submission of a supplement."
url: "https://uscodex.org/cfr/21/170.280"
---

# §170.280. Submission of a supplement.


If circumstances warrant, you may submit a supplement to a filed GRAS notice after we respond to your notice by letter in accordance with [§ 170.265(b)(1)](/cfr/21/170.265.md?p=b-1) or cease to evaluate your notice in accordance with [§ 170.265(b)(3)](/cfr/21/170.265.md?p=b-3).


## Notes

### Source

Source: 81 FR 55048, Aug. 17, 2016, unless otherwise noted.

### Authority

Authority: 21 U.S.C. 321, 341, 342, 346a, 348, 371.

### Source

Source: 42 FR 14483, Mar. 15, 1977, unless otherwise noted.