---
kind: "section"
citation: "21 C.F.R. § 170.22"
title: "21"
number: "170.22"
heading: "Safety factors to be considered."
url: "https://uscodex.org/cfr/21/170.22"
---

# §170.22. Safety factors to be considered.


In accordance with section 409(c)(5)(C) of the Act, the following safety factors will be applied in determining whether the proposed use of a food additive will be safe: Except where evidence is submitted which justifies use of a different safety factor, a safety factor in applying animal experimentation data to man of 100 to 1, will be used; that is, a food additive for use by man will not be granted a tolerance that will exceed 1/100th of the maximum amount demonstrated to be without harm to experimental animals.


## Notes

### Authority

Authority: 21 U.S.C. 321, 341, 342, 346a, 348, 371.

### Source

Source: 42 FR 14483, Mar. 15, 1977, unless otherwise noted.